Vavasour Irene M, Vafai Nasim, Beauchemin Philippe, Kanjilal Chironjeev, Badalan Alexandru, Shahinfard Elham, Laule Cornelia, Li David Kb, Traboulsee Anthony, Sossi Vesna, Kolind Shannon H, Carruthers Robert L
Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Medicine (Neurology), University of British Columbia, Vancouver, Canada.
Mult Scler Relat Disord. 2022 Dec;68:104238. doi: 10.1016/j.msard.2022.104238. Epub 2022 Oct 17.
MRI-based myelin water fraction (MWF) and PET-based Pittsburgh compound B (PiB) imaging both have potential to measure myelin in multiple sclerosis (MS). We characterised the differences in MWF and PiB binding in MS lesions relative to normal-appearing white matter and assessed the correlation between MWF and PiB binding in 11 MS participants and 3 healthy controls within 14 white matter regions of interest. Both PiB binding and MWF were reduced in MS lesions relative to NAWM, and a modest within subject correlation between MWF and PiB binding was found. This pilot study shows that MWF and PET-PiB provide different information about myelin loss in MS.
基于磁共振成像（MRI）的髓磷脂水含量（MWF）和基于正电子发射断层扫描（PET）的匹兹堡化合物B（PiB）成像都有潜力用于测量多发性硬化症（MS）中的髓磷脂。我们描述了MS病变中MWF和PiB结合相对于正常外观白质的差异，并评估了11名MS参与者和3名健康对照在14个白质感兴趣区域内MWF与PiB结合之间的相关性。相对于正常外观白质（NAWM），MS病变中的PiB结合和MWF均降低，并且发现MWF与PiB结合之间存在适度的受试者内相关性。这项初步研究表明，MWF和PET-PiB提供了关于MS中髓磷脂丢失的不同信息。
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