基质金属蛋白酶与心脑血管及神经退行性疾病风险的Meta 分析。
Meta-Analysis of Matrix Metalloproteinases in the Risk of Cardiovascular and Neurodegenerative Diseases.
机构信息
Department of Cardiovascular, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
Department of Breast Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
出版信息
Biomed Res Int. 2022 Oct 13;2022:3360316. doi: 10.1155/2022/3360316. eCollection 2022.
OBJECTIVE
To investigate the risk of cardiovascular and neurodegenerative diseases induced by matrix metalloproteinases (MMPs) by meta-analysis.
METHODS
Relevant literature was searched from Wanfang Medical Center, CNQI, VIP, PubMed, and other domestic and foreign literature databases for the research direction, and the risk of cardiovascular and neurodegenerative diseases induced by MMPs was meta-analyzed using the fixed-effect model and random-effect model.
RESULTS
MMP-1 and MMP-9 were risk factors for cardiovascular diseases by fixed and random-effect model analysis, respectively, while MMP-2 and MMP-9 were risk factors for increased neurodegenerative diseases by random-effect model analysis.
CONCLUSION
MMP-1 and MMP-9 are risk factors for cardiovascular diseases, and MMP-2 and MMP-9 are major factors for increased risk of neurodegenerative diseases. MMP-1, MMP-2, and MMP-9 can be used as new targets for clinical diagnosis, treatment, and research of subsequent cardiovascular and neurodegenerative diseases.
目的
通过荟萃分析研究基质金属蛋白酶（MMPs）引起的心血管和神经退行性疾病的风险。
方法
在万方医学中心、中国生物医学文献数据库、维普、PubMed 等国内外文献数据库中搜索相关文献，针对研究方向进行荟萃分析，采用固定效应模型和随机效应模型分析 MMPs 引起的心血管和神经退行性疾病的风险。
结果
固定效应模型分析显示 MMP-1 和 MMP-9 是心血管疾病的危险因素，而随机效应模型分析显示 MMP-2 和 MMP-9 是神经退行性疾病风险增加的危险因素。
结论
MMP-1 和 MMP-9 是心血管疾病的危险因素，MMP-2 和 MMP-9 是神经退行性疾病风险增加的主要因素。MMP-1、MMP-2 和 MMP-9 可作为临床诊断、治疗和后续心血管和神经退行性疾病研究的新靶点。
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