College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Department of Respirology, First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China.
Biomolecules. 2022 Oct 2;12(10):1410. doi: 10.3390/biom12101410.
Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniques to improve RA bioavailability and provide a mechanistic discussion of RA regarding tumor prevention, treatment, and adjuvant therapy. RA exhibits anticancer activity by regulating oxidative stress, chronic inflammation, cell cycle, apoptosis, and metastasis. These data suggest that daily use of RA-enriched dietary supplements can contribute to tumor prevention and treatment. RA has the potential for application in anti-tumor drug development.
癌症严重威胁人类健康和生活质量，是全球发病率和死亡率的主要原因之一。天然膳食产品因其易得性和无毒性而在癌症治疗和预防方面引起了广泛关注。迷迭香酸（RA）具有良好的抗氧化特性，在预防和抑制肿瘤方面安全有效。本综述总结了 RA 丰富的膳食补充剂的培养技术、提取工艺和抗肿瘤应用的最新研究进展。我们讨论了提高 RA 生物利用度的技术，并对 RA 在肿瘤预防、治疗和辅助治疗方面的作用机制进行了讨论。RA 通过调节氧化应激、慢性炎症、细胞周期、细胞凋亡和转移来发挥抗癌作用。这些数据表明，日常使用 RA 丰富的膳食补充剂有助于预防和治疗肿瘤。RA 具有在抗肿瘤药物开发中的应用潜力。
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