Continuous Oral Administration of Sonicated Delays Rat Skeletal Muscle Healing Post-Treadmill Training.

BACKGROUND

A delay in muscle repair interferes with the effect of training or exercise; therefore, it is important to identify the factors that delay muscle repair. , one of the most common periodontal disease pathogens, has the potential to inhibit muscle repair after training, as inferred from a previous study. To assess the expression of satellite cells in this in vivo study, we evaluated the relationship between and muscle regeneration after training.

METHODS

A total of 20 male Wistar rats (eight weeks in age) were randomly divided into two groups: one orally administered sonicated four times per week for six weeks (PG group) and one given no treatment (NT group). After four weeks of training using a treadmill, the gastrocnemius was evaluated using histology of the cross-sectional area (CSA) of myotubes and immunohistochemistry of the expression of skeletal muscle satellite cells. In addition, an endurance test was performed a day before euthanization.

RESULTS

The CSA and expression of Pax7+/MyoD- and Pax7+/MyoD+ cells were not significantly different between the groups. However, the expression of Pax7-/MyoD+ cells and running time until exhaustion were significantly lower in the PG group.

CONCLUSIONS

Infection with likely interferes with muscle repair after training.