Al-Qadami Ghanyah H, Secombe Kate R, Subramaniam Courtney B, Wardill Hannah R, Bowen Joanne M
School of Biomedicine, University of Adelaide, Adelaide, SA 5005, Australia.
The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Microorganisms. 2022 Oct 17;10(10):2048. doi: 10.3390/microorganisms10102048.
The gut microbiota has emerged as a key modulator of cancer treatment responses in terms of both efficacy and toxicity. This effect is clearly mediated by processes impacting the activation and modulation of immune responses. More recently, the ability to regulate chemotherapeutic drug metabolism has also emerged as a key driver of response, although the direct mechanisms have yet to be fully elucidated. Through fermentation, the gut microbiota can produce several types of metabolites, including short-chain fatty acids (SCFAs). SCFAs play an important role in maintaining epithelial barrier functions and intestinal homeostasis, with recent work suggesting that SCFAs can modulate response to cancer treatments and influence both anti-tumor immune response and inflammatory-related side effects. In this review, we will discuss the importance of SCFAs and their implications for cancer treatment response and toxicities.
肠道微生物群已成为癌症治疗反应在疗效和毒性方面的关键调节因子。这种效应显然是由影响免疫反应激活和调节的过程介导的。最近，调节化疗药物代谢的能力也已成为反应的关键驱动因素，尽管其直接机制尚未完全阐明。通过发酵，肠道微生物群可以产生几种类型的代谢物，包括短链脂肪酸（SCFA）。SCFA在维持上皮屏障功能和肠道内环境稳定方面发挥着重要作用，最近的研究表明，SCFA可以调节对癌症治疗的反应，并影响抗肿瘤免疫反应和炎症相关的副作用。在这篇综述中，我们将讨论SCFA的重要性及其对癌症治疗反应和毒性的影响。
