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孕期的癌症治疗与免疫疗法。

Cancer Treatment and Immunotherapy during Pregnancy.

作者信息

Koutras Antonios, Ntounis Thomas, Fasoulakis Zacharias, Papalios Theodoros, Pittokopitou Savia, Prokopakis Ioannis, Syllaios Athanasios, Valsamaki Asimina, Chionis Athanasios, Symeonidis Panagiotis, Samara Athina A, Pagkalos Athanasios, Pergialiotis Vasilios, Theodora Marianna, Antsaklis Panos, Daskalakis Georgios, Kontomanolis Emmanuel N

机构信息

1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece.

1st Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Agiou Thoma Str. 17, 11527 Athens, Greece.

出版信息

Pharmaceutics. 2022 Sep 29;14(10):2080. doi: 10.3390/pharmaceutics14102080.

Abstract

BACKGROUND/AIM: Immunotherapy has, in recent years, witnessed an expansion in its indications for the treatment of cancer. Coupled with the fact that, nowadays, even more women choose to postpone parenthood, thus increasing their chances of having some kind of malignancy during pregnancy, more and more women are eligible for receiving immunotherapy during this period of their lives. The cases of cancer diagnosed during pregnancy is an ever-increasing trend nowadays.

MATERIALS AND METHODS

The oncologists and clinicians treating women often face a range of ethical and therapeutic dilemmas due to the particularity of the patient's conditions. The primary concern is the protection of the mother, firstly, and then the fetus (through adjustments to the various treatment regimens) if possible.

RESULTS AND CONCLUSIONS

Oncological drugs, radiation therapy, surgery, or a combination of all the above methods are selected, depending on the case. In this project, we studied the oncology drugs used for various types of gestational cancer, their appropriateness and timing, as well as their possible effects on the parent and embryo upon their administration. Various studies have shown that the administration of oncological drugs should be postponed until at least after the first trimester of pregnancy.

摘要

背景/目的:近年来,免疫疗法在癌症治疗中的应用范围不断扩大。再加上如今越来越多的女性选择推迟生育,从而增加了孕期患某种恶性肿瘤的几率,越来越多的女性在其人生的这一阶段有资格接受免疫疗法。如今,孕期诊断出癌症的病例呈不断上升趋势。

材料与方法

由于患者病情的特殊性,治疗女性患者的肿瘤学家和临床医生常常面临一系列伦理和治疗困境。首要关注点是保护母亲,其次,如果可能的话,还要保护胎儿(通过调整各种治疗方案)。

结果与结论

根据具体情况选择肿瘤药物、放射治疗、手术或上述所有方法的组合。在本项目中,我们研究了用于各类妊娠期癌症的肿瘤药物、其适用性和使用时机,以及给药后对母体和胚胎可能产生的影响。各项研究表明,肿瘤药物的给药应至少推迟到妊娠头三个月之后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb6c/9611953/914118b5d53d/pharmaceutics-14-02080-g002.jpg

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