Napolitano Luigi, Pandolfo Savio Domenico, Aveta Achille, Cirigliano Lorenzo, Martino Raffaele, Mattiello Gennaro, Celentano Giuseppe, Barone Biagio, Rosati Claudia, La Rocca Roberto, Spena Gianluca, Spirito Lorenzo
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Front Reprod Health. 2022 Mar 22;4:791330. doi: 10.3389/frph.2022.791330. eCollection 2022.
Varicocele is a pathologic dilation of the testicular veins within the spermatic cord. Varicocele is considered the most common problem in reproductive medicine practice. It is identified in 15% of healthy men and up to 35% of men with primary infertility. The exact pathophysiology of varicoceles is not very well understood, and several theories have been proposed to explain it. Varicocele can impair sperm quality and fertility various mechanisms: reflux of adrenal metabolites, increased testicular hypoxia, oxidative stress, and increased testicular temperature have been proposed. Several studies have reported the significant benefits on semen parameters with the surgical treatment of varicocele: reducing oxidatively induced sperm DNA damage and potentially improving fertility. Varicocele repair should be offered as a part of treatment option for male partners of infertile couples presenting with palpable varicoceles. Nowadays, there are several surgical approaches available for the treatment of varicocele, such as the retroperitoneal approach, inguinal approach, and the subinguinal approach. The subinguinal microscopic approach offers the best outcomes, such as shorter hospital stays, preservation of the testicular arteries and lymphatics, least number of postoperative complications, recurrence, and a higher number of pregnancies. Currently robotic-assisted laparoscopic surgery is widely adopted in urology and surgeons began to explore the potential applications of the robotic platform to male infertility microsurgical operations. Robotic approach offers many advantages: elimination of tremor, retraction with third arm, high quality, 3-dimensional visualization and surgeon ergonomics, all contributing to the precision of surgery.
精索静脉曲张是精索内睾丸静脉的病理性扩张。精索静脉曲张被认为是生殖医学实践中最常见的问题。在15%的健康男性以及高达35%的原发性不育男性中可发现该病症。精索静脉曲张的确切病理生理学尚未完全明确,目前已提出多种理论来解释。精索静脉曲张可通过多种机制损害精子质量和生育能力:肾上腺代谢产物反流、睾丸缺氧增加、氧化应激以及睾丸温度升高都被提及。多项研究报告了精索静脉曲张手术治疗对精液参数有显著益处:减少氧化诱导的精子DNA损伤并可能提高生育能力。对于不育夫妇中可触及精索静脉曲张的男性伴侣,精索静脉曲张修复应作为治疗选择的一部分。如今,有多种手术方法可用于治疗精索静脉曲张,如腹膜后途径、腹股沟途径和腹股沟下途径。腹股沟下显微镜手术方法效果最佳,例如住院时间更短、保留睾丸动脉和淋巴管、术后并发症最少、复发率低且妊娠率更高。目前机器人辅助腹腔镜手术在泌尿外科广泛应用,外科医生开始探索机器人平台在男性不育显微手术中的潜在应用。机器人手术方法具有诸多优势:消除震颤、用第三臂进行牵拉、高质量的三维可视化以及外科医生操作的人体工程学设计,所有这些都有助于提高手术的精确性。