[Clinico-electrographic correlates of free radical pathology in epileptic patients].

In a series of 62 patients with variable forms of epileptic attacks the electrochemiluminescent (ECL) parameters of free radical oxidation (FRO) and antioxidant activity (AOA), the content of malonic dialdehyde (MDA) and free fatty acids (FFA) in the blood and cerebrospinal fluid (CSF) were collated with clinico-electroencephalographic characteristics of the disease. The CSF of all patients showed intensified FRO and inhibited AOA which significantly prevailed in cases of uncontrolled paroxysms; for all cases a progressive course of the disease with the development of encephalopathy and psychopathologic syndromes was characteristic, as well as generalized and frequent attacks, the presence of extraparoxysmal epileptic patterns on the ECG and the postparoxysmal syndrome. The spectrum of FRO and AOA parameters in patients with "forced normalization" and signs of drug poisoning are similar to quantitative characteristics of FRO and AOA in cases of frequent attacks and EEG characteristics of the paroxysmal type. The results of the study allow the conclusion that FRO and the electrochemical substrate of epileptization are two parallel closely related processes.