通过随机光学重建显微镜（STORM）成像揭示细胞间隧道纳米管（TNTs）的结构和组织。
Revealing the structure and organization of intercellular tunneling nanotubes (TNTs) by STORM imaging.
作者信息
Huang Lilin, Zhang Jiao, Wu Zekai, Zhou Liangliang, Yu Bin, Jing Yingying, Lin Danying, Qu Junle
机构信息
Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University Shenzhen 518060 P. R. China
出版信息
Nanoscale Adv. 2022 Sep 8;4(20):4258-4262. doi: 10.1039/d2na00415a. eCollection 2022 Oct 11.
Tunneling nanotubes (TNTs) are nanoscale, actin-rich, transient intercellular tubes for cell-to-cell communication, which transport various cargoes between distant cells. The structural complexity and spatial organization of the involved components of TNTs remain unknown. In this work, the STORM super-resolution imaging technique was applied to elucidate the structural organization of microfilaments and microtubules in intercellular TNTs at the nanometer scale. Our results reveal different distributions of microfilaments and intertwined structures of microtubules in TNTs, which promote the knowledge of TNT communications.
隧道纳米管（TNTs）是纳米级的、富含肌动蛋白的瞬时细胞间管道，用于细胞间通讯，可在远距离细胞之间运输各种货物。TNTs相关成分的结构复杂性和空间组织仍然未知。在这项工作中，应用了STORM超分辨率成像技术来阐明细胞间TNTs中微丝和微管在纳米尺度上的结构组织。我们的结果揭示了TNTs中微丝的不同分布和微管的交织结构，这增进了对TNT通讯的认识。
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