子宫内治疗先天性膈疝。

In Utero Therapy for Congenital Diaphragmatic Hernia.

机构信息

Division of Pediatric Surgery, University of California San Francisco, 550 16th Street, San Francisco, San Francisco, CA 94158, USA; Department of Surgery, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA.

Division of Pediatric Surgery, University of California San Francisco, 550 16th Street, San Francisco, San Francisco, CA 94158, USA.

出版信息

Clin Perinatol. 2022 Dec;49(4):863-872. doi: 10.1016/j.clp.2022.07.008. Epub 2022 Oct 13.

DOI:10.1016/j.clp.2022.07.008

PMID:36328604

Abstract

Congenital diaphragmatic hernia is an anomaly that is often prenatally diagnosed and spans a wide spectrum of disease, with high morbidity and mortality associated with fetuses with severe defects. Congenital diaphragmatic hernia is thus an ideal target for fetal intervention. We review the literature on prenatal diagnosis, describe the history of fetal intervention for congenital diaphragmatic hernia, and discuss fetal endoscopic tracheal occlusion and the Tracheal Occlusion To Accelerate Lung growth trial results. Finally, we present preclinical studies for potential future directions.

摘要

先天性膈疝是一种常可在产前诊断的异常，其疾病谱广泛，伴有严重缺陷的胎儿发病率和死亡率均较高。因此，先天性膈疝是胎儿干预的理想靶点。我们对产前诊断的文献进行了回顾，描述了先天性膈疝胎儿干预的历史，并讨论了胎儿内镜气管阻塞术和气管阻塞加速肺生长试验的结果。最后，我们提出了潜在的未来研究方向的临床前研究。