新型冠状病毒肺炎疫苗接种后水通道蛋白4免疫球蛋白相关性视神经脊髓炎谱系障碍发病：系统评价
Aquaporin-4 IgG neuromyelitis optica spectrum disorder onset after Covid-19 vaccination: Systematic review.
作者信息
Harahsheh Ehab, Callister Marcus, Hasan Shemonti, Gritsch David, Valencia-Sanchez Cristina
机构信息
Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
出版信息
J Neuroimmunol. 2022 Dec 15;373:577994. doi: 10.1016/j.jneuroim.2022.577994. Epub 2022 Oct 28.
Neuromyelitis optica spectrum disorder (NMOSD) is rarely reported following Coronavirus disease 2019 (COVID-19) vaccination. We identified 16 cases of new onset NMOSD with positive aquaporin-4 IgG (AQP4-IgG) following COVID-19 vaccination. Transverse myelitis was the most common clinical presentation (75%). Most patients received high dose steroids for acute treatment and maintenance therapy was started in 12 patients (75%). Twelve patients (75%) had improvement of their symptoms at the time of discharge or follow-up. The included cases share similar epidemiology and natural course to non-vaccine related cases. Clinicians should be aware of possible post-vaccination NMOSD to help with earlier diagnosis and treatment.
视神经脊髓炎谱系障碍（NMOSD）在2019冠状病毒病（COVID-19）疫苗接种后鲜有报道。我们确定了16例在COVID-19疫苗接种后新发的水通道蛋白4免疫球蛋白G（AQP4-IgG）阳性的NMOSD病例。横贯性脊髓炎是最常见的临床表现（75%）。大多数患者接受了大剂量类固醇进行急性治疗，12例患者（75%）开始了维持治疗。12例患者（75%）在出院或随访时症状有所改善。纳入病例与非疫苗相关病例具有相似的流行病学特征和自然病程。临床医生应意识到接种疫苗后可能发生的NMOSD，以帮助早期诊断和治疗。
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