非肾移植受者的症状性BK病毒膀胱炎
Symptomatic BK virus cystitis in non-renal transplant recipients.
作者信息
Almarhabi Hassan, Rotstein Coleman
机构信息
Transplant Infectious Diseases, Division of Infectious Diseases and Multi-Organ Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.
出版信息
J Assoc Med Microbiol Infect Dis Can. 2019 Jun 17;4(2):102-107. doi: 10.3138/jammi.2018-0035. eCollection 2019 Jun.
BACKGROUND
BK virus is implicated most commonly in causing BK virus-associated nephropathy in renal transplant recipients. However, on rare occasions, it can also produce symptomatic cystitis in other solid organ transplant recipients.
METHODS
Retrospective review of 2,149 non-renal solid organ transplant recipients over a 6-year period to evaluate patients for cases of symptomatic BK virus cystitis.
RESULTS
Three patients (two heart transplant recipients and one lung transplant recipient) are reported herein with symptomatic BK virus cystitis. These patients responded to reduced immunosuppressive medication with a reduction in viral load in two instances, and the third patient appeared to have an apparent response to prolonged levofloxacin treatment.
CONCLUSIONS
A high index of suspicion should be exercised in non-renal solid organ transplant recipients (particularly heart and lung transplant recipients) who have symptoms consistent with cystitis but have a negative urine bacterial culture.
背景
BK病毒最常与肾移植受者发生BK病毒相关性肾病有关。然而，在极少数情况下，它也可在其他实体器官移植受者中引起症状性膀胱炎。
方法
回顾性分析2149例非肾实体器官移植受者在6年期间的情况，以评估有症状性BK病毒膀胱炎病例的患者。
结果
本文报告了3例有症状性BK病毒膀胱炎的患者（2例心脏移植受者和1例肺移植受者）。这些患者通过减少免疫抑制药物治疗，2例患者的病毒载量降低，第3例患者似乎对延长左氧氟沙星治疗有明显反应。
结论
对于有膀胱炎症状但尿细菌培养阴性的非肾实体器官移植受者（尤其是心脏和肺移植受者），应保持高度怀疑。
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