Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Sci Rep. 2022 Nov 7;12(1):18854. doi: 10.1038/s41598-022-23747-z.
This study aimed to explore the effects on resorption of cervical disc herniation (CDH) and clinical outcomes of surgery. Cervical microendoscopic laminoplasty (CMEL), which is commonly preferable to anterior corpectomy and fusion, was applied to patients with 1- to 3-level degenerative cervical myelopathy (DCM). DCM patients with 1-3 levels DCM underwent either conservation treatment or CMEL. In conservation-treated patients (53 cases), CDH volume remained unchanged with no improvement in JOA and VAS scores. Conversely, 63 patients with 1-3 levels DCM were prospectively enrolled and exhibited a profound decrease in CDH volume: 89.1% of CDHs (123/138) regressed over 10%, 64.5% of CDHs (89/138) regressed over 25%, while 27.5% and 6.5% of CDHs (38/138 and 9/138) largely regressed over 50% and 75%, respectively. Meanwhile, the JOA and VAS scores were improved in different ways. Intriguingly, CDH volume changes correlated significantly with elevations in JOA scores, indicating an association of clinical CDH resolution with neurological recovery. We showed that CMEL induced clinically related diminishment of CDH and alleviation of clinical symptoms in patients with 1- to 3-level myelopathy and that it could help avoid anterior dissection of the disc to some extent.
本研究旨在探讨颈椎间盘突出症(CDH)吸收的影响及手术的临床效果。颈椎微内镜椎板成形术(CMEL)通常优于前路椎体切除术和融合术,适用于 1-3 个节段退行性颈椎病(DCM)患者。1-3 个节段 DCM 患者行保守治疗或 CMEL。在保守治疗组(53 例)中,CDH 体积保持不变,JOA 和 VAS 评分无改善。相反,前瞻性纳入了 63 例 1-3 个节段 DCM 患者,结果显示 CDH 体积明显减少:123/138(89.1%)个 CDH 退缩超过 10%,89/138(64.5%)个 CDH 退缩超过 25%,38/138(27.5%)和 9/138(6.5%)个 CDH 退缩超过 50%和 75%。同时,JOA 和 VAS 评分也有不同程度的改善。有趣的是,CDH 体积变化与 JOA 评分的升高显著相关,表明临床 CDH 缓解与神经功能恢复有关。我们表明,CMEL 可引起 1-3 个节段脊髓病患者的 CDH 明显缩小和临床症状缓解,并且在某种程度上可以避免椎间盘的前路切开。