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液相色谱串联质谱在精准医学中的应用进展

[Application progress of liquid chromatography tandem mass spectrometry in precision medicine].

作者信息

Jin J Y, Qiu F R, Zhang J

机构信息

Laboratory of Clinical Pharmacokinetics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Nov 6;56(11):1675-1684. doi: 10.3760/cma.j.cn112150-20211207-01128.

Abstract

Liquid chromatography tandem mass spectrometry (LC-MS/MS) is an analytical method that combines high separation of liquid chromatography with high selectivity and sensitivity of mass spectrometry. In recent years, LC-MS/MS has been widely used in clinical practice, including screening of inherited disorders, determination of endogenous compounds and analysis of biomarkers. LC-MS/MS is of great value to the precision prevention, diagnosis and treatment of some diseases due to its accurate data. This article not only illustrates the advantages of LC-MS/MS in precision medicine, but also prospects the future trend of LC-MS/MS in clinical practice, which expects to promote the development of clinical LC-MS/MS in the prevention, diagnosis and treatment of diseases.

摘要

液相色谱串联质谱法(LC-MS/MS)是一种将液相色谱的高分离能力与质谱的高选择性和高灵敏度相结合的分析方法。近年来,LC-MS/MS已广泛应用于临床实践,包括遗传性疾病筛查、内源性化合物测定和生物标志物分析。由于其数据准确,LC-MS/MS对某些疾病的精准预防、诊断和治疗具有重要价值。本文不仅阐述了LC-MS/MS在精准医学中的优势,还展望了LC-MS/MS在临床实践中的未来趋势,期望推动临床LC-MS/MS在疾病预防、诊断和治疗方面的发展。

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