不同紫外线波长对新型冠状病毒的灭活能力比较。
Comparison of the inactivation capacity of various UV wavelengths on SARS-CoV-2.
作者信息
Matsuura Ryosuke, Lo Chieh-Wen, Ogawa Takayo, Nakagawa Masaru, Takei Masami, Matsumoto Yasunobu, Wada Satoshi, Aida Yoko
机构信息
Laboratory of Global Infectious Diseases Control Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamichou, Itabashi-ku, Tokyo, 173-8610, Japan.
出版信息
Biochem Biophys Rep. 2022 Dec;32:101379. doi: 10.1016/j.bbrep.2022.101379. Epub 2022 Nov 7.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemic. Ultraviolet (UV) is regarded as a very powerful tool against SARS-CoV-2. However, the inactivating effects of different UV wavelengths on SARS-CoV-2 under the same conditions have hardly been compared. Here, we showed that SARS-CoV-2 cultured in Dulbecco's modified Eagle's medium and 2% fetal bovine serum was efficiently inactivated by irradiation with 222, 254, and 265 wavelengths UV, but not at 308 nm. In addition, it was revealed that UV absorption by DMEM-2% FBS is very efficient at 222 nm. Our results present potentially important information for selecting the optimum UV wavelength according to the application.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了全球大流行。紫外线（UV）被视为对抗SARS-CoV-2的一种非常有效的工具。然而，在相同条件下，不同紫外线波长对SARS-CoV-2的灭活效果几乎没有被比较过。在此，我们表明，在杜氏改良 Eagle 培养基和2%胎牛血清中培养的SARS-CoV-2，通过222、254和265波长的紫外线照射可被有效灭活，但在308 nm波长下则不能。此外，还发现DMEM-2% FBS在222 nm处对紫外线的吸收非常有效。我们的结果为根据应用选择最佳紫外线波长提供了潜在的重要信息。
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