Institute of Biomedical Sciences/Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Institute of Biomedical Sciences/Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Life Sci. 2022 Dec 15;311(Pt B):121191. doi: 10.1016/j.lfs.2022.121191. Epub 2022 Nov 12.
Eosinophils are multitasking granulocytes with implications for allergies, host response to helminths and, more recently, described roles in immunomodulation, homeostasis and tissue remodeling. Eosinophils secrete their preformed granule proteins by different pathways, especially piecemeal degranulation and cytolysis with granule release. Currently, there are different insights related to eosinophils' functional roles and biology that deserve to be highlighted. Cytolysis with granule release has also been associated with DNA extracellular trap formation, one of the most intriguing, recently described mechanisms of leukocyte activation. Focusing on DNA extracellular trap release, there are lessons to be learned from neutrophils considering the multitasking roles of these structures in inflammation, and the mechanisms involved in their release. This review explores a comparative analysis of the current knowledge considering DNA traps extrusion in neutrophils and eosinophils and update the major findings regarding the presence of these entities in eosinophilic-associated immune responses, inflammation and diseases.
嗜酸性粒细胞是具有多功能的粒细胞，与过敏、宿主对寄生虫的反应有关，最近还描述了其在免疫调节、稳态和组织重塑中的作用。嗜酸性粒细胞通过不同途径分泌其预先形成的颗粒蛋白，特别是颗粒释放的片段脱颗粒和细胞溶解。目前，与嗜酸性粒细胞的功能作用和生物学相关的不同见解值得强调。颗粒释放的细胞溶解也与 DNA 细胞外陷阱的形成有关，这是最近描述的白细胞激活的最有趣机制之一。专注于 DNA 细胞外陷阱的释放，从中性粒细胞中可以得到一些启示，因为这些结构在炎症中的多功能作用以及它们释放的机制。这篇综述探讨了比较分析当前关于中性粒细胞和嗜酸性粒细胞中 DNA 陷阱挤出的知识，并更新了关于这些实体在嗜酸性粒细胞相关免疫反应、炎症和疾病中的存在的主要发现。
