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基于多糖的水凝胶:伤口愈合的新见解与未来前景

Polysaccharide-based hydrogels: New insights and futuristic prospects in wound healing.

作者信息

Raina Neha, Pahwa Rakesh, Thakur Vijay Kumar, Gupta Madhu

机构信息

Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi 110017, India.

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India.

出版信息

Int J Biol Macromol. 2022 Dec 31;223(Pt A):1586-1603. doi: 10.1016/j.ijbiomac.2022.11.115. Epub 2022 Nov 14.

Abstract

Polysaccharides elicit enormous and promising applications due to their extensive obtainability, innocuousness, and biodegradability. Various outstanding features of polysaccharides can be employed to fabricate biomimetic and multifunctional hydrogels as efficient wound dressings. These hydrogels mimic the natural extracellular matrix and also boost the proliferation of cells. Owing to distinctive architectures and abundance of functional groups, polysaccharide-derived hydrogels have exceptional physicochemical properties and unique therapeutic interventions. Hydrogels designed using polysaccharides can effectively safeguard wounds from bacterial attack. This review includes wound physiology and emphasises on numerous polysaccharide-based hydrogels for wound repair applications. Polysaccharide hydrogels for different wound types and diverse therapeutic agents loaded in hydrogels for wound repair with recent patents are portrayed in the current manuscript, debating the potential of fascinating hydrogels for effective wound healing. More research is required to engineer multifaceted advanced polysaccharide hydrogels with tuneable and adjustable properties to attain huge potential in wound healing.

摘要

多糖因其广泛的可获取性、无害性和生物可降解性而具有巨大且前景广阔的应用。多糖的各种突出特性可用于制造仿生和多功能水凝胶作为高效的伤口敷料。这些水凝胶模仿天然细胞外基质,还能促进细胞增殖。由于独特的结构和丰富的官能团,多糖衍生的水凝胶具有优异的物理化学性质和独特的治疗作用。使用多糖设计的水凝胶可以有效保护伤口免受细菌侵袭。本综述包括伤口生理学,并着重介绍了众多用于伤口修复应用的基于多糖的水凝胶。当前手稿描绘了针对不同伤口类型的多糖水凝胶以及用于伤口修复的水凝胶中负载的各种治疗剂,并讨论了迷人的水凝胶在有效伤口愈合方面的潜力。需要更多研究来设计具有可调节和可调性质的多方面先进多糖水凝胶,以在伤口愈合中发挥巨大潜力。

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