Diabetology Clinic, Krompachy Hospital, Agel SK Inc., Krompachy, Slovakia.
Bioelectromagnetics. 2022 Oct;43(7):413-425. doi: 10.1002/bem.22425. Epub 2022 Nov 20.
Mounting evidence suggests enhanced blood pressure (BP) variability (BPV) independent role in cardiovascular (CV) damage. The goal was to estimate the effect of the carotid baroreceptor (CB) magnetic stimulation on sudden high BP elevation. Mean femoral arterial BP (MAP), heart rate (HR), baroreflex sensitivity (BRS), and ear lobe skin microcirculatory blood flow, by microphotoelectric plethysmography (MPPG), were simultaneously recorded in conscious rabbits sedated by pentobarbital intravenous (i.v.) infusion (5 mg/kg/h) after 40 min CB exposure to 350 mT static magnetic field (SMF), by Nd -Fe -B magnets (n = 14), or sham magnets exposure (n = 14). BRS was assessed from HR and MAP responses to abrupt hypotension induced by i.v. bolus injections of nitroprusside (Ni) and abrupt MAP elevation (MAP ) by i.v. bolus of phenylephrine (Ph). Beat-to-beat BPV was estimated by MAP standard deviation. SMF CB exposure significantly increased BRS (74.5 ± 17.8%, P < 0.001) and microcirculation (23.8% ± 11.0%, P = 0.039); decreased MAP (-5.7 ± 1.7%, P < 0.014) and phenylephrine-induced MAP (-19.1%, P = 0.043). MAP positively correlated with resting MAP (r = 0.342, P = 0.0383) and MAP SD (r = 0.383, P = 0.0194), and inversely with BRS (r = -0.47, P = 0.0156). SMF CB exposure enhanced the nitroprusside, which acts by releasing nitric oxide (NO), vasodilatory effect. This indicates arterial baroreflex to improve vessel sensitivity to NO, which is a new physiology with BP buffering effect. A positive correlation of MAP SD to phenylephrine BP ramps suggests a causal relationship and BPV prognostic significance to forecast abrupt BP elevation. Mechano/baroreceptor magneto-sensing property proposed to be the basic physiology by which SMFs boost CV autonomic regulation with potential implementation in high CV risk labile arterial hypertensive disease. © 2022 Bioelectromagnetics Society.
越来越多的证据表明，血压变异性（BPV）的增强独立于心血管（CV）损伤。本研究旨在评估颈动脉压力感受器（CB）磁刺激对突发性高血压升高的影响。在 40 分钟的 CB 暴露于 350 mT 静磁场（SMF）后，通过 Nd -Fe -B 磁铁（n = 14）或假磁体暴露（n = 14），静脉（i.v.）输注（5mg/kg/h）戊巴比妥钠使意识兔镇静后，同时记录股动脉平均血压（MAP）、心率（HR）、压力反射敏感性（BRS）和耳廊皮肤微循环血流，通过微光电体积描记法（MPPG）。BRS 是通过 HR 和 MAP 对静脉推注硝普钠（Ni）引起的急性低血压和静脉推注苯肾上腺素（Ph）引起的 MAP 急性升高的反应来评估的。通过 MAP 标准差估计逐搏 BPV。SMF CB 暴露显著增加了 BRS（74.5±17.8%，P<0.001）和微循环（23.8%±11.0%，P=0.039）；降低 MAP（-5.7±1.7%，P<0.014）和苯肾上腺素诱导的 MAP（-19.1%，P=0.043）。MAP 与静息 MAP（r=0.342，P=0.0383）和 MAP SD（r=0.383，P=0.0194）呈正相关，与 BRS 呈负相关（r=-0.47，P=0.0156）。SMF CB 暴露增强了硝普钠的作用，硝普钠通过释放一氧化氮（NO）而起作用。这表明动脉压力反射可以提高血管对 NO 的敏感性，这是一种具有血压缓冲作用的新生理学。MAP SD 与苯肾上腺素血压斜坡的正相关提示因果关系和血压变异性的预后意义，以预测突发性血压升高。提出机械/压力感受器磁感觉特性是 SMF 增强 CV 自主调节的基本生理学，可能在高 CV 风险不稳定动脉高血压疾病的实施中。
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