嗜黏蛋白阿克曼氏菌通过肠-肾轴改善慢性肾脏病间质纤维化。
Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis.
作者信息
Pei Tingting, Hu Rong, Wang Fujing, Yang Sixia, Feng Haitong, Li Qiye, Zhang Jiaxing, Yan Shihua, Ju Liliang, He Zhuoen, Han Zhongxiao, Yang Aicheng, Xiao Wei, Ma Yun, Wang Mingqing
机构信息
Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Nephropathy Center, The Affiliated Jiangmen TCM Hospital, Jinan University, Jiangmen, 529030, China.
出版信息
Microb Pathog. 2023 Jan;174:105891. doi: 10.1016/j.micpath.2022.105891. Epub 2022 Nov 23.
CONTEXT
Chronic kidney disease (CKD) affects approximately 10% of the global population. The abundance of Akkermansia muciniphila (AKK) is significantly reduced in CKD patients.
OBJECTIVE
This study investigated the effects of AKK bacteria on kidney damage and the renal interstitium in rats with CKD.
MATERIALS AND METHODS
CKD model 5/6 nephrectomy rats were used. CKD rats were supplemented with AKK (2 × 10 cfu/0.2 mL) for 8 weeks.
RESULTS
AKK administration significantly suppressed epithelial-mesenchymal transition (EMT), and high-throughput 16S rRNA pyrosequencing showed that AKK supplementation restored the disordered intestinal microecology in CKD rats. AKK also enhanced the intestinal mucosal barrier function. AKK may regulate the intestinal microecology and reduce renal interstitial fibrosis by enhancing the abundance of probiotics and reducing damage to the intestinal mucosal barrier.
CONCLUSION
The results suggest that AKK administration could be a novel therapeutic strategy for treating renal fibrosis and CKD.
背景
慢性肾脏病（CKD）影响着全球约10%的人口。在CKD患者中，嗜黏蛋白阿克曼氏菌（AKK）的丰度显著降低。
目的
本研究调查了AKK菌对CKD大鼠肾损伤及肾间质的影响。
材料与方法
采用CKD模型5/6肾切除大鼠。给CKD大鼠补充AKK（2×10⁸cfu/0.2 mL），持续8周。
结果
给予AKK可显著抑制上皮-间质转化（EMT），高通量16S rRNA焦磷酸测序显示，补充AKK可恢复CKD大鼠紊乱的肠道微生态。AKK还增强了肠道黏膜屏障功能。AKK可能通过增加益生菌丰度和减少对肠道黏膜屏障的损伤来调节肠道微生态并减轻肾间质纤维化。
结论
结果表明，给予AKK可能是治疗肾纤维化和CKD的一种新的治疗策略。
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