Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Łukasiewicza 1, 85-821 Bydgoszcz, Poland.
Department of Obstetrics and Gynecology, St. Adalbert's Hospital in Gdańsk, Copernicus Healthcare Entity, Jana Pawła II 50, 80-462 Gdańsk, Poland.
Cells. 2022 Nov 21;11(22):3690. doi: 10.3390/cells11223690.
At the end of gestation, the cervical tissue changes profoundly. As a result of these changes, the uterine cervix becomes soft and vulnerable to dilation. The process occurring in the cervical tissue can be described as cervical ripening. The ripening is a process derivative of enzymatic breakdown and inflammatory response. Therefore, it is apparent that cervical remodeling is a derivative of the reactions mediated by multiple factors such as hormones, prostaglandins, nitric oxide, and inflammatory cytokines. However, despite the research carried out over the years, the cellular pathways responsible for regulating this process are still poorly understood. A comprehensive understanding of the entire process of cervical ripening seems crucial in the context of labor induction. Greater knowledge could provide us with the means to help women who suffer from dysfunctional labor. The overall objective of this review is to present the current understanding of cervical ripening in terms of molecular regulation and cell signaling.
在妊娠末期，宫颈组织发生深刻变化。由于这些变化，子宫颈变得柔软，容易扩张。宫颈组织中发生的过程可以描述为宫颈成熟。成熟是酶解和炎症反应的结果。因此，很明显，宫颈重塑是由多种因素（如激素、前列腺素、一氧化氮和炎症细胞因子）介导的反应的衍生物。然而，尽管多年来进行了研究，但负责调节这个过程的细胞途径仍知之甚少。全面了解宫颈成熟的整个过程对于引产至关重要。更多的知识可以为我们提供帮助那些患有功能失调性劳动的女性的手段。本综述的总体目标是从分子调控和细胞信号转导的角度介绍宫颈成熟的最新认识。
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