PET Center, Department of Nuclear Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Theranostics. 2022 Oct 24;12(17):7404-7419. doi: 10.7150/thno.75279. eCollection 2022.
Cerenkov radiation (CR) from radionuclides and megavoltage X-ray radiation can act as an light source for deep cancer theranostics, overcoming the limitations of external light sources. Despite the blue-weighted emission and low quantum yield of CR, activatable probes-mediated CR can enhance the diagnostic signals by Cerenkov resonance energy transfer and also can produce therapeutic effects by reactive species generation/drug release, greatly promoting the biomedical applications of CR. In this review, we describe the principles and sources of CR, construction of CR-activated probes and their application to tumor optical imaging and therapy. Finally, future prospects for the design and biomedical application of CR-activated probes are discussed.
切伦科夫辐射（CR）来自放射性核素和兆伏级 X 射线辐射，可以作为深部癌症治疗的 光源，克服了外部光源的局限性。尽管 CR 的发射呈蓝光偏倚且量子产率低，但可激活探针介导的 CR 可以通过切伦科夫共振能量转移来增强 诊断信号，还可以通过产生活性物质/药物释放来产生治疗效果，从而极大地促进了 CR 在生物医学中的应用。在本文中，我们描述了 CR 的原理和来源，CR 激活探针的构建及其在肿瘤光学成像和治疗中的应用。最后，讨论了 CR 激活探针的设计和生物医学应用的未来前景。
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