通过时间分辨晶体学和量子化学计算洞察光敏蛋白的结构动力学。
Insight into the structural dynamics of light sensitive proteins from time-resolved crystallography and quantum chemical calculations.
作者信息
Weik Martin, Domratcheva Tatiana
机构信息
Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, F-38044 Grenoble, France.
Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia; Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
出版信息
Curr Opin Struct Biol. 2022 Dec;77:102496. doi: 10.1016/j.sbi.2022.102496. Epub 2022 Nov 30.
The structural dynamics underlying molecular mechanisms of light-sensitive proteins can be studied by a variety of experimental and computational biophysical techniques. Here we review recent progress in combining time-resolved crystallography at X-ray free electron lasers and quantum chemical calculations to study structural changes in photoenzymes, photosynthetic proteins, photoreceptors, and photoswitchable fluorescent proteins following photoexcitation.
可以通过多种实验和计算生物物理技术来研究光敏蛋白分子机制背后的结构动力学。在此，我们综述了结合X射线自由电子激光的时间分辨晶体学和量子化学计算来研究光酶、光合蛋白、光感受器以及光开关荧光蛋白在光激发后结构变化方面的最新进展。
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