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扭转发展,一个潜在新基因的诞生。

Twisting development, the birth of a potential new gene.

作者信息

Marsch-Martínez Nayelli, Reyes-Olalde J Irepan, Chalfun-Junior Antonio, Bemer Marian, Durán-Medina Yolanda, Ochoa-Sánchez Juan Carlos, Guerrero-Largo Herenia, Herrera-Ubaldo Humberto, Mes Jurriaan, Chacón Alejandra, Escobar-Guzmán Rocio, Pereira Andy, Herrera-Estrella Luis, Angenent Gerco C, Delaye Luis, de Folter Stefan

机构信息

Biotechnology and Biochemistry Department, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Irapuato, Mexico.

Unidad de Genómica Avanzada (UGA-Langebio), CINVESTAV-IPN, Irapuato, Mexico.

出版信息

iScience. 2022 Nov 19;25(12):105627. doi: 10.1016/j.isci.2022.105627. eCollection 2022 Dec 22.

Abstract

Evolution has long been considered to be a conservative process in which new genes arise from pre-existing genes through gene duplication, domain shuffling, horizontal transfer, overprinting, retrotransposition, etc. However, this view is changing as new genes originating from non-genic sequences are discovered in different organisms. Still, rather limited functional information is available. Here, we have identified (), a possible -originated protein-coding gene that modifies microtubule arrangement and causes helicoidal growth in when its expression is increased. Interestingly, even though is a likely recent gene, the lack of function affects . development. seems to have originated from a non-genic sequence. If so, it would be one of the few examples to date of how during evolution genes are integrated into developmental cellular and organismal processes.

摘要

长期以来,进化一直被认为是一个保守的过程,在这个过程中,新基因通过基因复制、结构域改组、水平转移、重叠基因、逆转录转座等方式从已有的基因中产生。然而,随着在不同生物体中发现源自非基因序列的新基因,这种观点正在发生变化。尽管如此,可用的功能信息仍然相当有限。在这里,我们鉴定出了(),一个可能起源于非基因的蛋白质编码基因,当它的表达增加时,会改变微管排列并导致(某生物体)呈螺旋状生长。有趣的是,尽管(该基因)可能是一个近期出现的基因,但缺乏(该基因的)功能会影响(某生物体的)发育。(该基因)似乎起源于一个非基因序列。如果是这样,它将是迄今为止少数几个关于在进化过程中(新)基因如何整合到发育细胞和生物体过程中的例子之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccbd/9713375/2fa421153956/fx1.jpg

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