比较ARIA-E严重程度量表及治疗管理阈值的影响。
Comparing ARIA-E severity scales and effects of treatment management thresholds.
作者信息
Klein Gregory, Scelsi Marzia A, Barakos Jerome, Fiebach Jochen B, Bracoud Luc, Suhy Joyce, Delmar Paul, Lyons Marco, Wojtowicz Jakub, Bullain Szofia, Barkhof Frederik, Purcell Derk
机构信息
F. Hoffmann-La Roche Ltd Basel Switzerland.
Roche Products Ltd. Welwyn Garden City UK.
出版信息
Alzheimers Dement (Amst). 2022 Dec 2;14(1):e12376. doi: 10.1002/dad2.12376. eCollection 2022.
INTRODUCTION
Amyloid-related imaging abnormalities-edema (ARIA-E) is associated with anti-amyloid beta monoclonal antibody treatment. ARIA-E severity may be assessed using the Barkhof Grand Total Scale (BGTS) or the 3- or 5-point Severity Scales of ARIA-E (SSAE-3/SSAE-5). We assessed inter- and intra-reader correlations between SSAE-3/5 and BGTS.
METHODS
Magnetic resonance imaging scans were collected from 75 participants in the SCarlet RoAD and Marguerite RoAD studies. Three neuroradiologists reviewed scans at baseline and at follow-up. Concordance in dichotomized ARIA-E ratings was assessed for a range of BGTS thresholds.
RESULTS
SSAE-3/5 scores correlated with BGTS scores, with high inter-reader intraclass correlation coefficients across all scales. There was high agreement in dichotomized ratings for SSAE-3 > 1 versus BGTS > 3 for all readers (accuracy 0.85-0.93) and between pairs of readers.
DISCUSSION
SSAE-3/5 showed high degrees of correlation with BGTS, potentially allowing seamless transition from the BGTS to SSAE-3/5 for ARIA-E management.
引言
淀粉样蛋白相关成像异常-水肿（ARIA-E）与抗淀粉样蛋白β单克隆抗体治疗相关。ARIA-E的严重程度可使用巴克霍夫总分量表（BGTS）或ARIA-E严重程度3分或5分量表（SSAE-3/SSAE-5）进行评估。我们评估了SSAE-3/5与BGTS之间的阅片者间及阅片者内相关性。
方法
收集了来自“猩红色之路”和“玛格丽特之路”研究中75名参与者的磁共振成像扫描数据。三名神经放射科医生在基线和随访时对扫描结果进行了评估。针对一系列BGTS阈值，评估了二分法ARIA-E评级的一致性。
结果
SSAE-3/5评分与BGTS评分相关，所有量表的阅片者间组内相关系数均较高。对于所有阅片者（准确率0.85-0.93）以及阅片者对之间，SSAE-3>1与BGTS>3的二分法评级具有高度一致性。
讨论
SSAE-3/5与BGTS显示出高度相关性，这可能允许在ARIA-E管理中从BGTS无缝过渡到SSAE-3/5。
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