全胃肠道菌群移植治疗肠漏综合征和菌群缺失
Total Gastrointestinal Flora Transplantation in the Treatment of Leaky Gut Syndrome and Flora Loss.
作者信息
Kanlioz Murat, Ekici Ugur, Ferhatoğlu Murat Ferhat
机构信息
General Surgery, Flora Transplantation Instutite, Istanbul, TUR.
General Surgery, İstanbul Gelisim University, Istanbul, TUR.
出版信息
Cureus. 2022 Nov 3;14(11):e31071. doi: 10.7759/cureus.31071. eCollection 2022 Nov.
Introduction The aim of this work was to treat patients with leaky gut syndrome (LGS) and gastrointestinal flora loss in a simple, inexpensive, permanent and effective way without the need for further treatment. Methods A total gastrointestinal flora transplantation (TGFT) procedure is performed by simultaneously transferring the "flora" taken from approximately 30 different anatomical sites, from the mouth to the anus, of healthy donors to the corresponding anatomical site of the patient using the endoscopic lavage method. Results Of the patients, 25 (44.6%) were female and 31 (55.4%) were male, totaling 56 (100%). The mean age was 32.88±15.78 years. Among the 56 patients enrolled in the study, TGFT had no efficacy in one patient, five patients underwent repeat TGFT during a mean follow-up period of 23.73±16.74 months, and the treatment was permanent in 50 patients; our success rate during the follow-up period was 89.3%. Conclusion In LGS, TGFT should be the gold standard treatment.
引言 本研究旨在以一种简单、廉价、持久且有效的方式治疗患有肠漏综合征（LGS）和胃肠道菌群失调的患者，无需进一步治疗。方法 通过内镜灌洗法，将取自健康供体从口腔至肛门约30个不同解剖部位的“菌群”同时转移至患者相应解剖部位，进行全胃肠道菌群移植（TGFT）操作。结果 患者中，女性25例（44.6%），男性31例（55.4%），共56例（100%）。平均年龄为32.88±15.78岁。在纳入研究的56例患者中，1例患者TGFT无效，5例患者在平均23.73±16.74个月的随访期内接受了重复TGFT，50例患者治疗效果持久；随访期内我们的成功率为89.3%。结论 在LGS中，TGFT应成为金标准治疗方法。
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