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卡介苗疫苗瘢痕与 2019 年冠状病毒病的关系。

Association between presence of Bacillus Calmette-Guerin vaccine scar and coronavirus disease 2019.

机构信息

Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Cerrahpasa Faculty of Medicine, Department of Public Health, Istanbul University-Cerrahpasa, Istanbul, Turkey.

出版信息

Medicine (Baltimore). 2022 Dec 2;101(48):e32185. doi: 10.1097/MD.0000000000032185.

Abstract

Bacillus Calmette-Guerin vaccine is administered for protection against tuberculosis and may also have beneficial effects against some viral respiratory tract infections. In this study, it was aimed to investigate the relationship between Bacillus Calmette-Guerin vaccination which is confirmed by BCG scar, and the frequency and course of Coronavirus disease 2019 (COVID-19). Among 490 patients, 400 patients who accepted to participate in the study were included. After the consent of patients, age, gender, body mass index, comorbidities, smoking, history, and the progress of COVID-19 of these patients were investigated; the presence and number of Bacillus Calmette-Guerin scars were recorded by a physician. Data from groups with and without COVID-19 history were compared. There was no relation between presence and number of the BCG scar and COVID-19 related hospitalization and intensive care unit admission. When groups with and without COVID-19 history compared, no statistically significant difference was found with the presence and number of Bacillus Calmette-Guerin scars (P > 0,05). No association was found between the presence or number of BCG scars and the frequency and course of COVID-19 in individuals with Bacillus Calmette-Guerin vaccination history confirmed by the presence of Bacillus Calmette-Guerin vaccine scars. Currently, the most important protection against COVID-19 is the COVID-19 vaccine.

摘要

卡介苗疫苗可用于预防结核病,并且可能对某些病毒性呼吸道感染具有有益作用。在这项研究中,旨在调查由卡介苗疤痕证实的卡介苗接种与 2019 年冠状病毒病(COVID-19)的频率和病程之间的关系。在 490 名患者中,有 400 名患者同意参加研究。在获得患者同意后,调查了这些患者的年龄,性别,体重指数,合并症,吸烟,病史以及 COVID-19的进展情况;由医师记录卡介苗疤痕的存在和数量。比较了有和没有 COVID-19 病史的组。BCG 疤痕的存在和数量与 COVID-19 相关的住院和重症监护病房入院之间没有关系。比较有和没有 COVID-19 病史的组时,BCG 疫苗疤痕的存在和数量没有统计学差异(P>0.05)。在有卡介苗疫苗疤痕存在的卡介苗接种史的个体中,BCG 疤痕的存在或数量与 COVID-19 的频率和病程之间没有关联。目前,预防 COVID-19 的最重要措施是 COVID-19 疫苗。

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