利用组织工程学构建皮肤癌模型。
Leveraging Tissue Engineering for Skin Cancer Models.
机构信息
Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
The Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA.
出版信息
Adv Exp Med Biol. 2023;1410:97-113. doi: 10.1007/5584_2022_755.
Bioengineered in vitro three-dimensional (3D) skin model has emerged as a promising tool for recapitulating different types of skin cancer and performing pre-clinical tests. However, a full-thickness 3D model including the epidermis, dermis, and hypodermis layers is scarce despite its significance in human physiology and diverse biological processes. In this book chapter, an attempt has been made to summarize various skin cancer models, including utilized skin layers, materials, cell lines, specific treatments, and fabrication techniques for three types of skin cancer: melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Subsequently, current limitations and future directions of skin cancer models are discussed. The knowledge of the current status of skin cancer models can provide various potential applications in cancer research and thus a more effective way for cancer treatment.
生物工程体外三维（3D）皮肤模型已成为重现不同类型皮肤癌并进行临床前测试的有前途的工具。然而，尽管其在人体生理学和多种生物学过程中具有重要意义，但包括表皮、真皮和皮下组织层的全厚 3D 模型仍然稀缺。在本章中，我们尝试总结了各种皮肤癌模型，包括使用的皮肤层、材料、细胞系、针对三种皮肤癌（黑色素瘤、基底细胞癌 (BCC) 和鳞状细胞癌 (SCC)）的特定治疗方法和制造技术。随后，讨论了皮肤癌模型的当前局限性和未来方向。了解皮肤癌模型的现状可以为癌症研究提供各种潜在的应用，并为癌症治疗提供更有效的方法。
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