Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden.
Skåne University Hospital, Lund and Malmö, Sweden.
Pediatr Rheumatol Online J. 2022 Dec 9;20(1):114. doi: 10.1186/s12969-022-00765-9.
Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.
The south-Swedish JIA cohort (n = 640), a population-based cohort with validated JIA diagnosis 1980 - 2010 and comparators, a reference group of 3200 individuals free from JIA, matched for sex, year of birth and residential region, was used. Data on comorbid diagnosis with depression or anxiety were obtained from the Skåne Healthcare Register, containing all healthcare contacts in the region, from 1998 to 2019. We used Cox proportional models for the calculation of hazard ratios.
During the study period, 1998 to 2019, 93 (14.5%) of the individuals in the JIA group were diagnosed with depression, and 111 (17.3%) with anxiety. Corresponding numbers among the references was 474 (14.8%) with depression and 557 (17.4%) with anxiety. Hazard ratio for depression was 1.1 (95% CI 0.9 - 1.5) in females and 0.8 (95% CI 0.5 - 1.4) in males, and for anxiety 1.2 (95% CI 0.9 - 1.5) in females and 0.6 (95% CI 0.4 - 1.1) in males. There were no statistically significant hazard ratios when analyzing subgroups of JIA patients with long disease duration or treatment with disease-modifying antirheumatic drugs.
Individuals with JIA do not have any statistically increased risk of being diagnosed with depression or anxiety compared to matched references.
患有慢性疾病的儿童被报道有更高的精神共病风险。很少有研究调查过幼年特发性关节炎（JIA）的这种风险，结果存在冲突。我们对瑞典南部患有幼年关节炎的患者进行了一项基于人群的纵向队列研究，以调查抑郁和焦虑的风险。
使用了瑞典南部 JIA 队列（n=640），这是一个基于人群的队列，其 JIA 诊断于 1980 年至 2010 年得到验证，以及对照组，即 3200 名无 JIA 的个体，他们在性别、出生年份和居住地区方面相匹配。从 1998 年至 2019 年，从斯科讷医疗保健登记处获得了合并诊断为抑郁或焦虑的患者数据，该登记处包含了该地区的所有医疗保健接触。我们使用 Cox 比例风险模型计算了风险比。
在研究期间，即 1998 年至 2019 年，JIA 组中有 93 名（14.5%）患者被诊断为抑郁症，111 名（17.3%）患者被诊断为焦虑症。对照组中相应的数字是 474 名（14.8%）患有抑郁症和 557 名（17.4%）患有焦虑症。女性的抑郁风险比为 1.1（95%CI 0.9-1.5），男性为 0.8（95%CI 0.5-1.4），女性的焦虑风险比为 1.2（95%CI 0.9-1.5），男性为 0.6（95%CI 0.4-1.1）。当分析患有长期疾病或接受疾病修饰抗风湿药物治疗的 JIA 患者亚组时，风险比没有统计学意义。
与匹配的对照组相比，JIA 患者被诊断为抑郁或焦虑的风险没有统计学上的增加。
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