Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada.
Molecules. 2022 Dec 6;27(23):8630. doi: 10.3390/molecules27238630.
The pancreas is a glandular organ with endocrine and exocrine functions necessary for the maintenance of blood glucose homeostasis and secretion of digestive enzymes. Pancreatitis is characterized by inflammation of the pancreas leading to temporary or permanent pancreatic dysfunction. Inflammation and fibrosis caused by chronic pancreatitis exacerbate malignant transformation and significantly increase the risk of developing pancreatic cancer, the world's most aggressive cancer with a 5-year survival rate less than 10%. Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation. The current review summarizes the existing in vitro and in vivo evidence on the effects of BBR against pancreatitis and pancreatic cancer with a focus on the signalling mechanisms underlying the effects of BBR.
胰腺是具有内分泌和外分泌功能的腺体器官，对于维持血糖内环境稳定和消化酶的分泌是必需的。胰腺炎的特征为胰腺炎症，导致胰腺的暂时或永久性功能障碍。慢性胰腺炎引起的炎症和纤维化会加剧恶性转化，并显著增加罹患胰腺癌的风险，胰腺癌是世界上侵袭性最强的癌症，其 5 年生存率不足 10%。小檗碱（BBR）是一种天然存在的植物衍生多酚，存在于各种草药中，用于传统医学治疗溃疡、感染、黄疸和炎症。本综述总结了 BBR 对抗胰腺炎和胰腺癌的现有体外和体内证据，重点介绍了 BBR 作用的信号机制。
