Emerg Infect Dis. 2022 Dec;28(13):S238-S243. doi: 10.3201/eid2813.212477.
In February 2021, Peru launched a COVID-19 vaccination campaign among healthcare personnel using an inactivated whole-virus vaccine. The manufacturer recommended 2 vaccine doses 21 days apart. We evaluated vaccine effectiveness among an existing multiyear influenza vaccine cohort at 2 hospitals in Lima. We analyzed data on 290 participants followed during February-May 2021. Participants completed a baseline questionnaire and provided weekly self-collected nasal swab samples; samples were tested by real-time reverse transcription PCR. Median participant follow-up was 2 (range 1-11) weeks. We performed multivariable logistic regression and adjusted for preselected characteristics. During the study, 25 (9%) participants tested SARS-CoV-2-positive. We estimated adjusted vaccine effectiveness at 95% (95% CI 70%-99%) among fully vaccinated participants and 100% (95% CI 88%-100%) among partially vaccinated participants. These data can inform the use and acceptance of inactivated whole-virus vaccine and support vaccination efforts in the region.
2021 年 2 月,秘鲁开始为医护人员接种使用灭活全病毒疫苗的新冠疫苗。制造商建议两剂疫苗间隔 21 天。我们在利马的两家医院对现有的多年流感疫苗队列进行了疫苗有效性评估。我们分析了 2021 年 2 月至 5 月期间 290 名参与者的随访数据。参与者完成了基线问卷调查,并每周提供自我采集的鼻拭子样本;样本通过实时逆转录聚合酶链反应进行检测。中位参与者随访时间为 2(范围 1-11)周。我们进行了多变量逻辑回归,并根据预先选择的特征进行了调整。在研究期间,有 25 名(9%)参与者的新冠病毒检测呈阳性。我们估计完全接种疫苗的参与者的疫苗调整后有效性为 95%(95%置信区间 70%-99%),部分接种疫苗的参与者的疫苗调整后有效性为 100%(95%置信区间 88%-100%)。这些数据可以为使用灭活全病毒疫苗提供信息,并支持该地区的疫苗接种工作。