角膜塑形术患者中 Corvis ST 测量的角膜生物力学重复性和相关性。

Repeatability and correlation of corneal biomechanical measurements obtained by Corvis ST in orthokeratology patients.

机构信息

Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Shandong, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong, China; School of Ophthalmology, Shandong First Medical University, Shandong, China.

出版信息

Cont Lens Anterior Eye. 2023 Jun;46(3):101793. doi: 10.1016/j.clae.2022.101793. Epub 2022 Dec 9.

DOI:10.1016/j.clae.2022.101793

PMID:36509642

Abstract

PURPOSE

To evaluate the repeatability of the corneal biomechanical measurements obtained by Corvis ST in post-orthokeratology patients and analyze the correlation between the biomechanical and ocular parameters.

METHODS

Fifty-one eyes of 51 myopic subjects were included in this study. The biomechanical parameters were assessed using Corvis ST. Repeatability was assessed using one-way ANOVA based on within-subject standard deviation (Sw), repeatability coefficient (RC), intraclass correlation coefficient (ICC) and correlation of variation (CoV). The correlation was evaluated using Pearson correlation analysis.

RESULTS

All parameters measured by Corvis ST, except length of flattened cornea at the first and second applanations (A1L and A2L), showed a good intraobserver repeatability after a 3-month follow-up period. The ICC values for A1L and A2L were 0.444 and 0.654, whereas the other parameters were higher than 0.8. Similar trends were obtained for CoV, wherein the CoV values for A1L and A2L were greater than 13 %. The corneal biomechanical parameters were correlated with age, refraction, axial length (AL), steep and flat keratometry before and after orthokeratology, and central corneal thickness (CCT). Following orthokeratology treatment, post-keratometry demonstrated a higher correlation with stiffness parameter at first applanation (SP-A1), velocity of corneal apex at the first applanation (A1V), and radius than pre-keratometry, which showed a weak correlation with SP-A1.

CONCLUSION

Corneal biomechanical parameters assessed using Corvis ST demonstrated a good repeatability, except A1L and A2L. The corneal biomechanical parameters were correlated with age, refraction, AL and pre- and post-keratometry. Thus, Corvis ST is a suitable device for investigating biomechanical parameter.

摘要

目的

评估角膜生物力学测量在角膜塑形术后患者中的重复性，并分析生物力学和眼部参数之间的相关性。

方法

本研究纳入了 51 名近视患者的 51 只眼。使用 Corvis ST 评估生物力学参数。采用基于个体内标准差（Sw）、重复性系数（RC）、组内相关系数（ICC）和变异系数（CoV）的单向方差分析评估重复性。采用 Pearson 相关分析评估相关性。

结果

Corvis ST 测量的所有参数，除第一次和第二次压平角膜长度（A1L 和 A2L）外，在 3 个月随访期间均表现出良好的观察者内重复性。A1L 和 A2L 的 ICC 值分别为 0.444 和 0.654，而其他参数均高于 0.8。CoV 也呈现出相似的趋势，A1L 和 A2L 的 CoV 值大于 13%。角膜生物力学参数与年龄、屈光度、眼轴长度（AL）、角膜塑形术前和术后的陡峭和扁平角膜曲率、中央角膜厚度（CCT）相关。角膜塑形术后，后角膜曲率与第一次压平的刚性参数（SP-A1）、第一次压平的角膜顶点速度（A1V）和半径相关性更高，与 SP-A1 的相关性较弱。