三日疟原虫：一种持久寄生虫的持续谜团。

Plasmodium malariae: the persisting mysteries of a persistent parasite.

作者信息

Culleton Richard, Pain Arnab, Snounou Georges

机构信息

Division of Molecular Parasitology, Proteo-Science Centre, Ehime University, Matsuyama, Japan; Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.

Pathogen Genomics Group, Bioscience Programme, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Kingdom of Saudi Arabia.

出版信息

Trends Parasitol. 2023 Feb;39(2):113-125. doi: 10.1016/j.pt.2022.11.008. Epub 2022 Dec 13.

DOI:10.1016/j.pt.2022.11.008

PMID:36517330

Abstract

Plasmodium malariae is a 'neglected malaria parasite' in as much as the amount of research conducted on it pales into insignificance when compared to that pertaining to Plasmodium falciparum and Plasmodium vivax, its more notorious and pathogenic cousins. There has, however, been an increase in interest in this parasite over the past decade. Principally, this is because of the increasing use of sensitive molecular detection techniques that have revealed a wider than previously recorded prevalence in some regions (particularly in Africa), and high numbers of chronic, asymptomatic infections.

摘要

与更臭名昭著且具有致病性的近亲恶性疟原虫和间日疟原虫相比，关于三日疟原虫的研究数量显得微不足道，因此它是一种“被忽视的疟原虫”。然而，在过去十年中，人们对这种寄生虫的兴趣有所增加。主要原因是，越来越多地使用敏感的分子检测技术，这些技术显示在一些地区（特别是非洲），三日疟原虫的流行率比以前记录的更广，并且存在大量慢性无症状感染。