Department of Pediatrics, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China.
Department of Infectious Disease, Kunming Children's Hospital, Kunming, Yunnan Province, China.
J Infect Dis. 2023 May 29;227(11):1313-1321. doi: 10.1093/infdis/jiac486.
Whether pediatric rotavirus infection is associated with extraintestinal complications remains unknown.
We conducted a case-control study to investigate the incidences and risks of rotavirus-associated extraintestinal complications in hospitalized newborns, infants, and children younger than 5 years.
A total of 1325 young inpatients with rotavirus infection (754 male and 539 newborns) and 1840 controls without rotavirus infection (1035 male and 836 newborns) were included. The incidences of neurological disease were higher among rotavirus individuals compared with controls: newborns, 7.24% (39/539) versus 2.87% (24/836), P < .001; infants and young children, 19.59% (154/786) versus 12.35% (124/1004), P < .001. The associated odd ratios (ORs) for neurological disease frequency following rotavirus infection was 2.64 (95% confidence interval [CI], 1.57-4.44) for newborns and 1.73 (95% CI, 1.34-2.24) for infants and young children, which increased to 2.56 (95% CI, 1.57-4.18) in case-control (1:1) matching analysis and 1.85 (95% CI, 1.41-2.42) in confounder adjustment. Rotavirus infection was associated with other extraintestinal complications, depending on study population and disease severity. Outcome analysis revealed rotavirus infection and its consequences had a significant impact on hospitalization and discharge.
Rotavirus exposure was associated with a spectrum of extraintestinal complications, particularly neurological disease. Rotavirus infection and subsequent consequences resulted in poor clinical outcomes.
小儿轮状病毒感染是否与肠道外并发症有关尚不清楚。
我们进行了一项病例对照研究，以调查住院新生儿、婴儿和 5 岁以下儿童中轮状病毒相关肠道外并发症的发生率和风险。
共纳入 1325 例轮状病毒感染的年轻住院患者（754 例男性和 539 例新生儿）和 1840 例无轮状病毒感染的对照者（1035 例男性和 836 例新生儿）。与对照组相比，轮状病毒感染者的神经系统疾病发生率更高：新生儿为 7.24%（39/539），而对照组为 2.87%（24/836），P<0.001；婴儿和幼儿为 19.59%（154/786），而对照组为 12.35%（124/1004），P<0.001。轮状病毒感染后神经系统疾病的关联比值比（OR）为新生儿为 2.64（95%置信区间[CI]，1.57-4.44），婴儿和幼儿为 1.73（95%CI，1.34-2.24），病例对照（1:1）匹配分析中增至 2.56（95%CI，1.57-4.18），混杂因素调整后为 1.85（95%CI，1.41-2.42）。轮状病毒感染与其他肠道外并发症有关，取决于研究人群和疾病严重程度。结果分析显示，轮状病毒感染及其后果对住院和出院有显著影响。
轮状病毒暴露与一系列肠道外并发症相关，特别是神经系统疾病。轮状病毒感染及其后续后果导致不良临床结局。
