Yao Hui, Zhang Dalin, Yu Hao, Shen Hui, Liu Hao, Meng Fanyue, Wu Xu, Zhang Guohua, Wang Xiaolong
Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, Liaoning, 110122, P. R. China; Key Laboratory of Forensic Bio-evidence Sciences, Shenyang, Liaoning, 110122, P. R. China; China Medical University Center of Forensic Investigation, Shenyang, Liaoning, 110122, P. R. China; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China.
Department of Thyroid Surgery, the 1st affiliated Hospital, China Medical University, Shenyang, Liaoning, 110001, P. R. China.
Physiol Behav. 2023 Mar 1;260:114056. doi: 10.1016/j.physbeh.2022.114056. Epub 2022 Dec 14.
The microbiota-gut-brain axis is a bidirectional regulatory pathway between the brain and the gastrointestinal tract, which plays an important role in maintain homeostasis. Gut microbiota could influence the behavior, cognition, stress response and others via the axis. Depression is a complex psychiatric disease, giving rise to heavy social health and economic burden. In recent years, studies have shown that the gut microbiota are closely linked to the pathophysiological processes of depression. In this article, the interaction and its underlying mechanisms between depression and gut microbiota were summarized.
微生物群-肠-脑轴是大脑与胃肠道之间的双向调节通路，在维持体内平衡中起重要作用。肠道微生物群可通过该轴影响行为、认知、应激反应等。抑郁症是一种复杂的精神疾病，会带来沉重的社会健康和经济负担。近年来，研究表明肠道微生物群与抑郁症的病理生理过程密切相关。本文综述了抑郁症与肠道微生物群之间的相互作用及其潜在机制。
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