Correlation analysis in a set of X-benzyltrimethylammonium derivatives with antimuscarinic activity.
作者信息
De Amici M, De Micheli C, Pratesi P, Grana E, Santagostino Barbone M G, Cappello B, Silipo C, Vittoria A
机构信息
Istituto di Chimica Farmaceutica, Università di Milano, Italy.
出版信息
Farmaco Sci. 1987 Jun;42(6):409-24.
PMID:3653389
Abstract
The results of a pharmacological investigation on a series of meta-substituted benzyltrimethylammonium salts possessing an antimuscarinic activity are reported. Correlative analysis shows that the pharmacodynamic activity is a function of the hydrophobic-lipophilic parameter associated with the substituent.
摘要
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