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肝硬化患者胆石症的管理

Management of Cholelithiasis in Cirrhotic Patients.

作者信息

Viscosi Francesca, Fleres Francesco, Cucinotta Eugenio, Mazzeo Carmelo

机构信息

Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Section of General Surgery, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

出版信息

J Pers Med. 2022 Dec 14;12(12):2060. doi: 10.3390/jpm12122060.

Abstract

Gallstone disease (GD) is a common disease worldwide and has a higher incidence in cirrhotic patients than in the general population. The main indications for cholecystectomy surgery in cirrhotic patients remain symptomatic cholelithiasis and its complications. Over the past two decades, numerous published reports have attested to the feasibility and safety of laparoscopic cholecystectomy in cirrhotic patients. Surgery in patients with liver cirrhosis represents an additional source of stress for an already impaired liver function and perioperative complications are remarkably high compared to non-cirrhotic patients, despite significant advances in surgical management. Therefore, preoperative risk stratification and adequate patient selection are mandatory to minimize postoperative complications. We have conducted a systematic review of the literature over the last 22 years for specific information on indications for surgery in cirrhotic patients and individual percentages of Child-Pugh grades undergoing treatment. There are very few reported cases of cholecystectomy and minimally invasive treatment, such as percutaneous transhepatic cholecystostomy (PTC), in patients with Child-Pugh grade C cirrhosis. With this work, we would like to pay attention to the treatment of cholelithiasis in cirrhotic patients who are still able to undergo cholecystectomy, thus also encouraging this type of intervention in cases of asymptomatic cholelithiasis in patients with Child-Pugh grades A and B.

摘要

胆结石病(GD)是一种全球常见疾病,在肝硬化患者中的发病率高于普通人群。肝硬化患者行胆囊切除术的主要指征仍然是有症状的胆石症及其并发症。在过去二十年中,大量已发表的报告证实了肝硬化患者行腹腔镜胆囊切除术的可行性和安全性。肝硬化患者的手术对本已受损的肝功能来说是额外的应激源,尽管手术管理有了显著进展,但与非肝硬化患者相比,围手术期并发症仍然非常高。因此,术前风险分层和适当的患者选择对于尽量减少术后并发症至关重要。我们对过去22年的文献进行了系统回顾,以获取有关肝硬化患者手术指征以及接受治疗的Child-Pugh分级个体百分比的具体信息。Child-Pugh C级肝硬化患者行胆囊切除术及微创治疗(如经皮经肝胆囊造瘘术(PTC))的报道病例非常少。通过这项工作,我们希望关注仍能接受胆囊切除术的肝硬化患者胆石症的治疗,从而也鼓励对Child-Pugh A级和B级患者的无症状胆石症进行此类干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b21/9786294/d30ae8d9ec40/jpm-12-02060-g001.jpg

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