在细胞水平对活体人类神经功能进行研究：追逐嵌合体？
Studying human neural function in vivo at the cellular level: Chasing chimeras?
作者信息
Vermaercke Ben, Bonin Vincent, Vanderhaeghen Pierre
机构信息
VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium; Neuro-Electronics Research Flanders, Kapeldreef 75, 3001 Leuven, Belgium.
Neuro-Electronics Research Flanders, Kapeldreef 75, 3001 Leuven, Belgium; Department of Biology, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium; imec, 3001 Leuven, Belgium.
出版信息
Cell. 2022 Dec 22;185(26):4869-4872. doi: 10.1016/j.cell.2022.11.020.
Despite its importance to understanding human brain (dys)function, it has remained challenging to study human neurons in vivo. Recent approaches, using transplantation of human cortical neurons into the rodent brain, offer new prospects for the study of human neural function and disease in vivo, from molecular to circuit levels.
尽管了解人类大脑（功能）障碍对研究人类大脑功能很重要，但在体内研究人类神经元仍然具有挑战性。最近，将人类皮质神经元移植到啮齿动物大脑中的方法为在体内从分子水平到电路水平研究人类神经功能和疾病提供了新的前景。
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