Caron Juliette, Graf Sahara, Delebarre-Sauvage Christine
Service d'allergologie et d'éducation thérapeutique, Hôpital Saint Vincent-de-Paul, Lille Cedex, France.
Délégation à la Recherche Clinique et à l'Innovation, Unité de Biostatistiques, Hôpital Saint Philibert, Lomme Cedex, France.
Clin Transl Allergy. 2022 Dec;12(12):e12214. doi: 10.1002/clt2.12214.
Among 74 patients with an immediate hypersensitivity reaction (IHR) to iodinated contrast media (ICM), the rate of allergic patients confirmed by positive prick test or diluted intradermal test (IDT) was 8.1%. 12.5% of re-exposed patients had a recurrent IHR despite negative skin tests. Investigations on pure IDT to ICM and development of drug provocation test may provide additional safety nets to uncover recurrent ICM reactors. Agreements among allergists are needed to unify practices.
在74例对碘化造影剂(ICM)有速发型超敏反应(IHR)的患者中,通过阳性点刺试验或稀释皮内试验(IDT)确诊的过敏患者比例为8.1%。尽管皮肤试验呈阴性,但12.5%的再次接触患者出现了复发性IHR。对ICM进行纯IDT研究和开展药物激发试验可能会提供额外的安全保障,以发现复发性ICM反应者。过敏症专科医生之间需要达成共识以统一操作规范。