基于列维奇方程的搅拌式微量滴定板通透性测定（PAMPA和Caco-2）中水性边界层的厚度。 - Suppr

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超能文献

Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation.

作者信息

Avdeef Alex

机构信息

in-ADME Research, 1732 First Avenue #102, New York, NY 10128 USA. E-mail:

出版信息

ADMET DMPK. 2022 Dec 6;10(4):249-252. doi: 10.5599/admet.1568. eCollection 2022.

DOI:10.5599/admet.1568

PMID:36578562

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9793457/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e1/9793457/e372ca7f4b45/ADMET-10-1568-g001.jpg

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本文引用的文献

Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists.

Drug Discov Today Technol. 2004 Dec;1(4):349-55. doi: 10.1016/j.ddtec.2004.11.013.

Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

Eur J Pharm Sci. 2005 Mar;24(4):333-49. doi: 10.1016/j.ejps.2004.11.011. Epub 2005 Jan 20.

PAMPA--a drug absorption in vitro model 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates.

Eur J Pharm Sci. 2004 Aug;22(5):365-74. doi: 10.1016/j.ejps.2004.04.009.

The size of the unstirred layer as a function of the solute diffusion coefficient.

Biophys J. 1998 Sep;75(3):1403-9. doi: 10.1016/S0006-3495(98)74058-5.

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.

J Med Chem. 1998 Mar 26;41(7):1007-10. doi: 10.1021/jm970530e.

Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.

J Pharm Sci. 1995 Oct;84(10):1197-204. doi: 10.1002/jps.2600841011.

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