呼吸道刺突 SARS-CoV-2 抗病毒免疫。
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract.
机构信息
Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Trends Immunol. 2023 Feb;44(2):87-89. doi: 10.1016/j.it.2022.12.007. Epub 2022 Dec 22.
The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent severe disease, but do not promote mucosal immunity. New data suggest how to boost systemic immunity and elicit pulmonary immunity in a way that more effectively controls infection and impairs transmission.
COVID-19 大流行推动了基于 mRNA 的疫苗的成功研发，这些疫苗经肌肉注射后可引发针对刺突蛋白的抗体，预防重症疾病，但不能促进黏膜免疫。新数据提示了如何增强全身免疫并引发肺部免疫，从而更有效地控制感染并降低传播风险。
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