一项随机对照试验研究了用母亲自己的奶进行口腔治疗对早产儿的影响。
A randomized controlled trial of oropharyngeal therapy with mother's own milk for premature infants.
机构信息
Department of Pediatrics, NorthShore University HealthSystem, Evanston, IL, USA.
University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
出版信息
J Perinatol. 2023 May;43(5):601-607. doi: 10.1038/s41372-022-01589-x. Epub 2023 Jan 3.
OBJECTIVE
To determine if oropharyngeal therapy with mother's own milk (OPT-MOM) reduces late-onset sepsis (L-OS; primary outcome), NEC, death, length of stay, time to full enteral nutrition (FEN) and full oral feeds in preterm infants (BW < 1250 g).
DESIGN
Infants (N = 220) were randomized to Group A (milk) or B (placebo) and received 0.2 mL every 2 h for 48 h, then every 3 h until 32 weeks CGA.
RESULTS
There were no significant differences in L-OS, NEC or death. Group A trended towards an 8-day reduction in stay, 8-day reduction in time to FEN and a 6-day reduction in time to full oral feeds, compared to B. While clinically relevant, due to large variability in outcomes and lack of power, p values were > 0.05.
CONCLUSION
OPT-MOM did not reduce L-OS, NEC or death. Group A trended towards a reduced stay and better nutritional outcomes, but results were not statistically significant.
CLINICALTRIALS
GOV: NCT02116699.
目的
确定口腔治疗母亲自己的奶（OPT-MOM）是否减少晚发性败血症（L-OS；主要结局）、NEC、死亡、住院时间、完全肠内营养（FEN）时间和早产儿（BW<1250g）完全口服喂养。
设计
将 220 名婴儿随机分为 A 组（奶）或 B 组（安慰剂），并在 48 小时内每 2 小时接受 0.2 毫升，然后每 3 小时接受 32 周 CGA。
结果
L-OS、NEC 或死亡无显著差异。与 B 组相比，A 组的住院时间减少 8 天，FEN 时间减少 8 天，完全口服喂养时间减少 6 天。虽然临床相关，但由于结果的变异性大且缺乏动力，p 值>0.05。
结论
OPT-MOM 并未减少 L-OS、NEC 或死亡。A 组的住院时间和营养结局有改善趋势，但结果无统计学意义。
临床试验
GOV：NCT02116699。
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