Møllgård Kjeld, Beinlich Felix R M, Kusk Peter, Miyakoshi Leo M, Delle Christine, Plá Virginia, Hauglund Natalie L, Esmail Tina, Rasmussen Martin K, Gomolka Ryszard S, Mori Yuki, Nedergaard Maiken
Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Science. 2023 Jan 6;379(6627):84-88. doi: 10.1126/science.adc8810. Epub 2023 Jan 5.
The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the subarachnoid space in the mouse and human brain, designated the subarachnoid lymphatic-like membrane (SLYM). SLYM is morpho- and immunophenotypically similar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases blood vessels and harbors immune cells. Functionally, the close apposition of SLYM with the endothelial lining of the meningeal venous sinus permits direct exchange of small solutes between cerebrospinal fluid and venous blood, thus representing the mouse equivalent of the arachnoid granulations. The functional characterization of SLYM provides fundamental insights into brain immune barriers and fluid transport.
中枢神经系统由脑膜包裹，传统上称为硬脑膜、蛛网膜和软脑膜。我们发现存在第四层脑膜，它将小鼠和人类大脑中的蛛网膜下腔分隔开来，称为蛛网膜下淋巴样膜（SLYM）。SLYM在形态和免疫表型上与外周器官和体腔的间皮膜相似，它包裹血管并容纳免疫细胞。在功能上，SLYM与脑膜静脉窦的内皮紧密相邻，允许脑脊液和静脉血之间直接交换小分子溶质，因此相当于小鼠的蛛网膜颗粒。SLYM的功能特性为脑免疫屏障和液体运输提供了基本见解。
