一名感染HIV的患者患原发性前列腺弥漫性大B细胞淋巴瘤。
Primary diffuse large B cell lymphoma of the prostate in a patient with HIV infection.
作者信息
Ujiie Takashi, Kawai Taketo, Kaneko Tomoyuki, Yamamoto Tadashi, Oshima Yasutoshi, Fujikura Mutsuo, Akiyama Nobu, Sasajima Yuko, Tashiro Haruko, Nakagawa Tohru
机构信息
Department of Urology Teikyo University School of Medicine Tokyo Japan.
Department of Internal Medicine Teikyo University School of Medicine Tokyo Japan.
出版信息
IJU Case Rep. 2022 Oct 5;6(1):30-32. doi: 10.1002/iju5.12541. eCollection 2023 Jan.
INTRODUCTION
Primary prostate lymphomas are very rare; however, the incidence of malignant lymphoma is high among HIV-infected patients. Herein, we report a case of primary diffuse large B-cell lymphoma (DLBCL) of the prostate in an HIV-infected patient.
CASE PRESENTATION
A 47-year-old man presented with miction pain and back pain. Abdominal CT revealed a huge prostate mass extending to the left retroperitoneum. Serum sIL-2R level was abnormally high (2896 U/mL), whereas PSA level was normal. HIV antigen and antibody tests were positive. The patient was diagnosed with DLBCL after a prostate biopsy. Systemic treatments were administered; however, the tumor was refractory, and the patient died 9 months after diagnosis.
CONCLUSION
Prostate malignant lymphomas are rare but should be considered in patients with enlarged prostates and normal PSA levels. It should be noted that HIV patients have a high incidence of malignant lymphomas.
引言
原发性前列腺淋巴瘤非常罕见；然而，在感染HIV的患者中恶性淋巴瘤的发病率很高。在此，我们报告一例感染HIV患者的原发性前列腺弥漫性大B细胞淋巴瘤（DLBCL）病例。
病例介绍
一名47岁男性因排尿疼痛和背痛就诊。腹部CT显示巨大的前列腺肿块延伸至左腹膜后。血清sIL-2R水平异常升高（2896 U/mL），而PSA水平正常。HIV抗原和抗体检测呈阳性。经前列腺活检后，该患者被诊断为DLBCL。给予了全身治疗；然而，肿瘤具有耐药性，患者在诊断后9个月死亡。
结论
前列腺恶性淋巴瘤罕见，但对于前列腺肿大且PSA水平正常的患者应予以考虑。应注意的是，HIV患者恶性淋巴瘤的发病率很高。
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