Department of Medicine, Division of Hematology, Oncology, & Cell Therapy, Rush University Medical Center, Chicago, IL 60612, USA.
Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA.
Cells. 2023 Jan 3;12(1):199. doi: 10.3390/cells12010199.
is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. In this review, we review the important acute and chronic infections caused by this pathogen. We next discuss various animal models which have been developed to evaluate pathogenesis and assess therapeutics against this pathogen. Next, we review current treatments (antibiotics and vaccines) and provide an overview of their efficacies and their limitations. Finally, we highlight exciting literature on novel antibiotic-free strategies to control infections.
是一种重要的革兰氏阴性机会致病菌,可引起多种严重的急性和慢性感染,发病率和死亡率高达 40%。使成为一个特别具有挑战性的病原体的原因是它对许多现有抗生素具有高度的内在和获得性耐药性。在这篇综述中,我们回顾了由这种病原体引起的重要的急性和慢性感染。接下来,我们讨论了已经开发出的各种动物模型,以评估发病机制并评估针对这种病原体的治疗方法。接下来,我们回顾了当前的治疗方法(抗生素和疫苗),并概述了它们的疗效及其局限性。最后,我们强调了关于控制感染的新型无抗生素策略的令人兴奋的文献。