基于天然产物的新型L-焦谷氨酸类似物的合成与抗真菌活性评价
Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues.
作者信息
Ai Likun, Fu Shiqi, Li Yong, Zuo Mei, Huang Wen, Huang Jian, Jin Zhichao, Chen Yang
机构信息
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
出版信息
Front Plant Sci. 2022 Dec 22;13:1102411. doi: 10.3389/fpls.2022.1102411. eCollection 2022.
Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against , , , , and showed moderate antifungal activity. For instance, and provide potential lead agents for controlling because of their inhibitory activity.
植物源农药是第三代农药的来源之一，近年来因其在自然界中可降解且无污染的优点而受到国内外广泛关注。本文探索了一种从L-羟脯氨酸合成一系列新型L-焦谷氨酸类似物的简洁方法。此外，这些磺酰酯衍生物对[具体真菌名称1]、[具体真菌名称2]、[具体真菌名称3]、[具体真菌名称4]和[具体真菌名称5]的生物活性研究显示出中等程度的抗真菌活性。例如，[化合物名称1]和[化合物名称2]因其抑制活性而提供了控制[具体真菌名称]的潜在先导药物。
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