Xu Tianren, Liu Xiaonan, Wang Shengguang, Kong Hongwei, Yu Xiaojun, Liu Congying, Song Huaying, Gao Peng, Zhang Xin
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Pharmacol. 2022 Dec 23;13:1039553. doi: 10.3389/fphar.2022.1039553. eCollection 2022.
(common name: Earthworm, Chinese name: dilong) has been used in traditional Chinese medicine for thousands of years. Recently, a few scientific studies have investigated the antifibrotic effects of Dilong extract (DE) and produced controversial results. We conducted a meta-analysis to make an informed decision on the antifibrotic effects of Dilong extract. The studies on antifibrotic effects of Dilong extract published until July 2022 in the scientific databases [PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), VIP database for Chinese Technical Periodicals, SinoMed and WanFang database] were reviewed. The RevMan 5.4.1 software was used for standardized mean difference (SMD) analysis. Two researchers independently reviewed all the studies, and their quality was assessed using the Cochrane risk of bias tool. A total of 325 studies were found in the scientific databases; however, only 13 studies met the criteria for analysis. Dilong extract treatment was associated with antifibrotic effects inhibiting the transforming growth factor beta 1 (TGF-β1, SMD = -3.16, 95% CI: -4.18, -2.14, < .00001) and alpha-smooth muscle actin (α-SMA: SMD = -2.57, 95% CI: -3.47, -1.66, < .00001). Dilong extract effectively reduces tissue fibrosis; thus, further scientific studies should be conducted to investigate and develop it for clinical use. https://www.crd.york.ac.uk/prospero/, identifier CRD42022357141.
地龙（俗名：蚯蚓，中文名：地龙）在传统中药中已使用了数千年。最近，一些科学研究调查了地龙提取物（DE）的抗纤维化作用，但结果存在争议。我们进行了一项荟萃分析，以便就地龙提取物的抗纤维化作用做出明智的决策。我们检索了截至2022年7月在科学数据库[PubMed、科学网、中国知网（CNKI）、中文科技期刊数据库（VIP）、中国生物医学文献数据库（SinoMed）和万方数据库]中发表的关于地龙提取物抗纤维化作用的研究。使用RevMan 5.4.1软件进行标准化均数差（SMD）分析。两名研究人员独立审查了所有研究，并使用Cochrane偏倚风险工具评估其质量。在科学数据库中总共发现了325项研究；然而，只有13项研究符合分析标准。地龙提取物治疗与抗纤维化作用相关，可抑制转化生长因子β1（TGF-β1，SMD = -3.16，95%CI：-4.18，-2.14，P <.00001）和α-平滑肌肌动蛋白（α-SMA：SMD = -2.57，95%CI：-3.47，-1.66，P <.00001）。地龙提取物可有效减轻组织纤维化；因此，应进行进一步的科学研究以对其进行研究并开发用于临床。https://www.crd.york.ac.uk/prospero/，标识符CRD42022357141。
Zotero 插件
