糖尿病视网膜病变中血清铁死亡相关生物标志物水平异常
Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy.
作者信息
Mu Lin, Wang Dahu, Dong Zhiguo, Wu Jiajun, Wu Xiaoyu, Su Jing, Zhang Yinjian
机构信息
Department of Ophthalmology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
出版信息
J Ophthalmol. 2022 Dec 30;2022:3353740. doi: 10.1155/2022/3353740. eCollection 2022.
PURPOSE
This study aimed to measure the concentrations of ferroptosis-related biomarkers, namely, iron (Fe), lipid peroxide (LPO), reactive oxygen species (ROS), glutathione peroxidase-4 (GPX4), and glutathione (GSH) in DR in the attempt to evaluate the diagnostic performance of these biomarkers.
METHODS
This study included 30 NPDR patients, 30 PDR patients, and 30 healthy subjects matched in age and sex. The concentrations of Fe, LPO, ROS, GPX4, and GSH in serum of the subjects were measured.
RESULTS
Compared with the normal group, GPX4 and GSH concentrations were significantly lower, and LPO, Fe, and ROS concentrations were significantly higher in DR patients. Compared with the PDR group, the NPDR group had higher concentrations of LPO, Fe, and ROS and lower concentrations of GPX4 and GSH, but there was no statistical difference in Fe, GPX4, and GSH. ROC curve shows that ferroptosis-related biomarkers have accumulated accuracy in NPDR and PDR.
CONCLUSION
This study shows that ferroptosis-related biomarkers may be involved in the pathological process of DR and can be used as one of the biomarkers of DR.
目的
本研究旨在测定糖尿病视网膜病变（DR）中与铁死亡相关的生物标志物的浓度，即铁（Fe）、脂质过氧化物（LPO）、活性氧（ROS）、谷胱甘肽过氧化物酶-4（GPX4）和谷胱甘肽（GSH），以评估这些生物标志物的诊断性能。
方法
本研究纳入30例非增殖性糖尿病视网膜病变（NPDR）患者、30例增殖性糖尿病视网膜病变（PDR）患者以及30例年龄和性别相匹配的健康受试者。测定受试者血清中Fe、LPO、ROS、GPX4和GSH的浓度。
结果
与正常组相比，DR患者的GPX4和GSH浓度显著降低，LPO、Fe和ROS浓度显著升高。与PDR组相比，NPDR组的LPO、Fe和ROS浓度较高，GPX4和GSH浓度较低，但Fe、GPX4和GSH无统计学差异。ROC曲线显示，与铁死亡相关的生物标志物在NPDR和PDR中具有累积准确性。
结论
本研究表明，与铁死亡相关的生物标志物可能参与DR的病理过程，可作为DR的生物标志物之一。
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