Windus D W, Stokes T J, Julian B A, Fenves A Z
Department of Medicine, Washington University Medical Center, St. Louis, Missouri.
Ann Intern Med. 1987 Nov;107(5):678-80. doi: 10.7326/0003-4819-107-5-678.
Four hemodialysis patients receiving deferoxamine for metal overload had fatal rhinocerebral rhizopus infections. Serious fungal infections are not commonly seen in patients on dialysis, and none of these patients had the usual risk factors for rhizopus infection. Deferoxamine is being used with increased frequency in dialysis patients for aluminum and iron overload states. We propose that there is a link between the deferoxamine therapy and this unusual infection. Deferoxamine may serve as a specific growth factor for Rhizopus species or may alter host immune function. We suggest searching for fungal organisms in patients with unexplained illnesses receiving deferoxamine.
四名接受去铁胺治疗金属过载的血液透析患者发生了致命的鼻脑根霉菌感染。严重的真菌感染在透析患者中并不常见，而且这些患者均无通常的根霉菌感染风险因素。在透析患者中，因铝和铁过载状态，去铁胺的使用频率正不断增加。我们认为去铁胺治疗与这种不寻常的感染之间存在关联。去铁胺可能是根霉菌属的一种特定生长因子，或者可能改变宿主免疫功能。我们建议在接受去铁胺治疗且患有不明疾病的患者中查找真菌病原体。
