横纹肌溶解症所致肾损伤的分子机制：从实验台到临床应用
Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside.
作者信息
Hebert Jessica F, Burfeind Kevin G, Malinoski Darren, Hutchens Michael P
机构信息
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA.
出版信息
Kidney Int Rep. 2022 Sep 30;8(1):17-29. doi: 10.1016/j.ekir.2022.09.026. eCollection 2023 Jan.
Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but other potential therapies, including pretreatments for those at risk for developing RIAKI, are under investigation. This review outlines the mechanisms and clinical significance of RIAKI, investigational treatments and their specific targets, and the status of ongoing research trials.
横纹肌溶解症诱导的急性肾损伤（RIAKI）发生在肌细胞膜鞘受损之后，导致肌红蛋白和其他代谢产物泄漏，进而造成肾损伤。目前，RIAKI唯一推荐的临床治疗方法是积极的液体复苏，但其他潜在疗法，包括对有发生RIAKI风险者的预处理，正在研究中。这篇综述概述了RIAKI的机制和临床意义、研究性治疗方法及其特定靶点，以及正在进行的研究试验的状况。
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