儿童眼眶脉管性畸形的患病率及临床特征。

Prevalence and clinical features of orbital vascular anomalies in children.

机构信息

Mayo Clinic Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

Department of Ophthalmology & Visual Sciences at the Medical College of Wisconsin, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

出版信息

Orbit. 2023 Dec;42(6):598-602. doi: 10.1080/01676830.2023.2166081. Epub 2023 Jan 16.

DOI:10.1080/01676830.2023.2166081

PMID:36644978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10691662/

Abstract

PURPOSE

To report the prevalence, clinical characteristics, and natural history of orbital vascular anomalies diagnosed among children over a 50-year period.

METHODS

The medical records of all patients <19 years diagnosed with any form of an orbital vascular anomaly (OVA) at Mayo Clinic, Rochester, Minnesota from January 1 1966, through December 31 2015, were retrospectively reviewed.

RESULTS

A total of 109 children were diagnosed with OVA during the 50-year period, of which 24 were from Olmsted County, MN, yielding a birth prevalence of 1 in 4,305 live births. The median age at diagnosis for the 109 patients was 1.2 years (range, 0-17.9 years) and 67 (61.5%) were female. Common presenting symptoms included proptosis in 80 (73.4%) patients, abnormalities in skin color in 45 (41.3%) patients, and pain in 18 (16.5%) patients. There were 55 (50.5%) vascular malformations [50 (91%) low-flow lymphatic malformations, 3 (5.5%) high-flow arteriovenous malformations, and 2 (3.5%) low-flow venous malformations] and 54 (49.5%) vascular tumors [53 (98%) capillary hemangiomas and 1 (2%) kaposiform hemangioendothelioma]. During a mean follow-up of 5.95 years (range 0-27.7 years), amblyopia and/or strabismus were diagnosed in 46 (43.4%) patients.

CONCLUSIONS

Capillary hemangiomas and low-flow lymphatic malformations comprise most of the orbital vascular anomalies in this cohort of children. Amblyopia and strabismus are common sequelae, highlighting the importance of early diagnosis and appropriate management.

摘要

目的

报告在 50 年期间诊断出的儿童眼眶血管畸形的患病率、临床特征和自然病史。

方法

回顾性分析 1966 年 1 月 1 日至 2015 年 12 月 31 日期间，明尼苏达州罗切斯特市梅奥诊所诊断出的任何形式眼眶血管畸形（OVA）的所有患者的病历。

结果

在 50 年期间，共有 109 名儿童被诊断出患有 OVA，其中 24 名来自明尼苏达州奥姆斯特德县，出生患病率为每 4305 例活产 1 例。109 例患者的中位诊断年龄为 1.2 岁（范围，0-17.9 岁），其中 67 例（61.5%）为女性。常见的首发症状包括 80 例（73.4%）患者的眼球突出，45 例（41.3%）患者的皮肤颜色异常，18 例（16.5%）患者的疼痛。有 55 例（50.5%）血管畸形[50 例（91%）低流量淋巴管畸形，3 例（5.5%）高流量动静脉畸形，2 例（3.5%）低流量静脉畸形]和 54 例（49.5%）血管肿瘤[53 例（98%）毛细血管血管瘤和 1 例（2%）卡波西样血管内皮瘤]。在平均 5.95 年（范围 0-27.7 年）的随访中，诊断出 46 例（43.4%）患者患有弱视和/或斜视。